Comprehensive Diagnosis and Management of Hypertensive Disease

Introduction

Managing hypertension is more than simply ordering medications—it requires a systematic approach to accurate blood pressure measurement, careful diagnosis, individualized treatment goals, and ongoing follow‐up. This guide integrates evidence‐based principles for antihypertensive drug ordering with practical strategies for the management of hypertensive disease, particularly in older adults.

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1. Accurate Blood Pressure Measurement & Diagnosis

Office Blood Pressure Measurement

• Method: Measure both arms simultaneously at the first visit.

• Interarm Difference:

  • If > 10 mmHg (confirmed on repeat), use the higher value for diagnosis.

  • A persistent difference of > 15–20 mmHg warrants investigation for arterial disease.

• Preparation: Ensure the patient is relaxed, seated for at least 5 minutes, and has not consumed caffeine, smoked, or exercised within 30 minutes.

Home Blood Pressure Monitoring (HBPM)

• Frequency:

  • For diagnosis: 7 consecutive days (3 days if urgent).

  • For treatment follow-up: 7 consecutive days 2 weeks after medication adjustments; then 1–2 times per week or 7 days before an appointment.

• Timing:

  • Morning: Within 1 hour after waking, after urination, and before medications/breakfast.

  • Evening: At bedtime.

• Technique: Take at least two readings per session, 1 minute apart.

Ambulatory Blood Pressure Monitoring (ABPM)

• Usage: Ideal for evaluating 24-hour blood pressure patterns and identifying nocturnal hypertension.

• Thresholds:

  • 24-hr average: SBP ≥ 130 mmHg and/or DBP ≥ 80 mmHg

  • Daytime: SBP ≥ 135 mmHg and/or DBP ≥ 85 mmHg

  • Nighttime: SBP ≥ 120 mmHg and/or DBP ≥ 70 mmHg

Diagnostic Criteria (Based on Measurement Method)

• Office: ≥ 140/90 mmHg

• HBPM: ≥ 135/85 mmHg

• ABPM: As noted above

  
  

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2. Hypertensive Disease in Older Adults: Special Considerations

Classification of Hypertension

• Optimal: SBP < 120 mmHg and DBP < 80 mmHg

• Normal: SBP 120–129 mmHg and/or DBP < 80 mmHg

• High-Normal (BP at risk): SBP 130–139 mmHg and/or DBP 80–89 mmHg

• Hypertension Grades:

  • Grade 1: SBP 140–159 mmHg and/or DBP 90–99 mmHg

  • Grade 2: SBP 160–179 mmHg and/or DBP 100–109 mmHg

  • Grade 3: SBP ≥ 180 mmHg and/or DBP ≥ 110 mmHg

• Special Forms:

  • Isolated Systolic Hypertension: SBP ≥ 140 mmHg with DBP < 90 mmHg

  • Isolated Diastolic Hypertension: SBP < 140 mmHg with DBP ≥ 90 mmHg

Treatment Goals by Age

• Ages 18–67: Target BP < 130/80 mmHg

• Ages 65–79: Target BP < 140/90 mmHg (< 130/80 if tolerated)

• Ages ≥ 80:

  • SBP target 140–150 mmHg; may consider 130–139 mmHg if tolerated

  • Avoid DBP < 60 mmHg to reduce risk of orthostatic hypotension

• For High CV Risk (e.g., DM, CKD, prior CVD): Stricter targets may be warranted.

Other Phenotypes in Older Adults

• White-Coat Hypertension: Elevated office BP but normal HBPM/ABPM; focus on lifestyle modification and risk factor reduction.

• Masked Hypertension: Normal office BP but elevated HBPM/ABPM; requires vigilant follow-up.

• Resistant/Refractory Hypertension:

  • Resistant HT: BP remains ≥ 140/90 mmHg despite 3 optimally dosed medications (including a diuretic).

  • Refractory HT: Uncontrolled BP despite ≥ 5 medications.

    
    

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3. Pre-Treatment Assessment & Lifestyle Modification

• Risk Stratification: Initiate medication when:

  • Average office SBP ≥ 130 and/or DBP ≥ 80 mmHg in patients with clinical CVD, diabetes, or high CV risk.

  • Average office SBP ≥ 140 and/or DBP ≥ 90 mmHg in the general population.

• Lifestyle Measures:

  • Diet modification (e.g., DASH diet, reduced sodium intake)

  • Weight management and regular physical activity

  • Smoking cessation and moderation of alcohol intake

    
    

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4. Principles of Antihypertensive Drug Therapy

General Medication Strategy

• Initial Therapy Options:

  • Preferred Combination: ACE inhibitor (or ARB) plus either a calcium channel blocker (CCB) or a thiazide/thiazide-like diuretic.

  • Monotherapy: May be indicated in frail or elderly patients (≥ 65 years) or those with significant comorbidities.

• Stepwise Dose Escalation:

  1. Start with one or two agents at a low dose (“start low, go slow”).

  2. Titrate to the maximum well-tolerated dose before adding another agent.

  3. Consider triple therapy (ACEi/ARB + CCB + Thiazide) if needed.

  4. For true-resistant hypertension, optimize diuretic therapy and consider additional agents (e.g., spironolactone, beta-blockers, hydralazine).

Medication Ordering: Key Considerations

Document the medication name, dose, route, and frequency clearly in the patient chart. Below is a summary table outlining commonly used antihypertensive agents:

Drug	Class	Usual Starting Dose	Typical Maximum Dose	Key Notes
Enalapril	ACE Inhibitor	5 mg PO once daily	40 mg/day (may divide BID)	Start low in frail/elderly; monitor renal function & potassium.
Losartan	ARB	50 mg PO once daily	100 mg/day	Can be dosed BID if needed; monitor renal function.
Amlodipine	CCB (Dihydropyridine)	5 mg PO once daily	10 mg/day	Titrate gradually; common side effect is peripheral edema.
Hydrochlorothiazide	Thiazide Diuretic	12.5 mg PO once daily (½ of 25 mg tab)	25 mg/day	Check electrolytes for hyponatremia & hypokalemia.
Chlorthalidone	Thiazide-like	12.5 mg PO once daily	25–50 mg/day	Preferred in resistant hypertension; monitor renal function.
Labetalol (Oral)	Alpha/Beta Blocker	100 mg PO twice daily	Up to 2400 mg/day (divided doses)	Useful in CKD and pregnancy; monitor for bradycardia.
Metoprolol Tartrate	Beta-Blocker	25 mg PO twice daily	Up to 450 mg/day (divided doses)	Caution in patients with asthma/COPD.

Note: Dosing must be individualized based on patient factors such as age, frailty, renal function, and comorbidities.

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5. A Step-by-Step Approach to Medication Ordering

Initial Combination Therapy (When Appropriate)

• Example Order:

  • Enalapril 5 mg PO once daily + Amlodipine 5 mg PO once daily

  • Rationale: Combining an ACE inhibitor with a CCB offers complementary mechanisms for blood pressure reduction while mitigating dose-related side effects.

Monotherapy in Specific Populations

• Frail/Elderly or Comorbid Patients:

  • Consider starting with a single agent (e.g., Enalapril 5 mg or Amlodipine 5 mg) and titrate slowly.

  • For very frail patients, a short-acting ACE inhibitor (e.g., Captopril) may be preferred for tighter control.

Dose Escalation & Adding Agents

1. Step 1: Maximize dose of initial agent(s) within tolerability limits.

2. Step 2: Add a second agent from a different class (e.g., ACEi/ARB + CCB or thiazide).

3. Step 3: If blood pressure remains uncontrolled, consider triple therapy and evaluate for resistant hypertension.

Special Situations

• Chronic Kidney Disease (CKD):

  • Use ACEi/ARB cautiously; consider lab-friendly options like labetalol.

• Heart Failure (HFrEF):

  • Prioritize ACEi/ARB/ARNI along with beta-blockers; add hydralazine (with nitrates) if ACEi/ARB is contraindicated.

• Pregnancy:

  • Labetalol, methyldopa, or long-acting nifedipine are preferred choices.

    
    

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6. Managing Resistant Hypertension

When blood pressure remains uncontrolled despite 3 or more medications (including a diuretic):

• Optimize Diuretic Therapy:

  • Switch to a thiazide-like diuretic (chlorthalidone or indapamide) or use a loop diuretic if eGFR is low.

• Add-On Therapy:

  • Consider low-dose spironolactone (25–50 mg/day) if renal function permits.

  • Evaluate the addition of beta-blockers or direct vasodilators (hydralazine), with careful monitoring.

• Switching Therapy:

  • In patients with heart failure, an ARNI (sacubitril/valsartan) may be considered after appropriate ACE inhibitor washout.

    
    

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7. Alternative Strategy with Less Laboratory Monitoring

For patients with limited access to frequent lab testing or borderline renal function, consider a sequential approach that minimizes electrolyte and renal monitoring:

1. Start with a CCB:

   • Amlodipine 5 mg PO once daily

2. Add a Beta-Blocker:

   • Metoprolol 25 mg PO twice daily

3. Add a Vasodilator:

   • Hydralazine 25 mg PO three times daily

4. Add an Alpha-Blocker (if needed):

   • Doxazosin 1 mg PO once daily

Benefits:

• Reduced risk of electrolyte disturbances

• Preservation of renal function

• Multi-mechanistic blood pressure control

• Simplified regimen potentially improving patient adherence

  
  

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8. Special Considerations in Older Adults

Treatment Adjustments

• Dosing: Start with lower doses and titrate gradually (“start low, go slow”) to reduce the risk of orthostatic hypotension.

• Medication Choice:

  • Avoid non-selective alpha-1 blockers (e.g., doxazosin) as first-line due to high risk of postural hypotension.

  • Avoid immediate-release nifedipine due to risks of precipitous hypotension and ischemia.

• Monitoring:

  • In older patients, ensure that diastolic pressures do not fall too low (avoid DBP < 60 mmHg) to maintain coronary perfusion.

Blood Pressure Targets in Older Adults

• General Office BP Targets:

  • Ages 65–79: Aim for < 140/90 mmHg (if tolerated, consider < 130/80 mmHg)

  • Ages ≥ 80: SBP target 140–150 mmHg, with lower targets (130–139 mmHg) if tolerated, ensuring DBP remains > 60 mmHg.

• Home BP Targets: May be adjusted based on individual cardiovascular risk profiles.

  
  

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9. Case Study Example

Patient: 67-year-old female with a 3-year history of hypertension

• Current Medications:

  • Enalapril 20 mg PO BID

  • Amlodipine 10 mg PO once daily

  • Hydrochlorothiazide 25 mg PO BID (morning and noon)

  • Atorvastatin 20 mg PO at bedtime

• Recent Office BP: ~160/90 mmHg after 5 minutes rest (consistent with her history)

• Symptoms: Dizziness and near-syncope

• Labs: K⁺ 4.6 mEq/L, Cr 0.75 mg/dL

Management Considerations:

• Reassessment: Ensure proper measurement technique.

• Next Step:

  • Given her symptoms and suboptimal BP control despite three agents, consider advising additional home blood pressure monitoring to confirm readings.

  • Evaluate for possible medication adjustments rather than immediately increasing diuretic dosage or adding another agent.

Appropriate action might be to “Advise home blood pressure monitoring and recording” to better assess her blood pressure pattern before making further adjustments.

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10. Conclusion

Effective management of hypertensive disease requires a comprehensive approach that blends accurate measurement, individualized diagnostic criteria, and thoughtful pharmacologic therapy. For older adults—who often present with complex comorbidities and greater sensitivity to medications—a tailored strategy that emphasizes “start low, go slow,” regular monitoring, and appropriate drug combinations is key. By integrating lifestyle modifications, adherence to current guidelines (such as those from the Thai Hypertension Society and other international bodies), and vigilant follow-up, clinicians can achieve optimal blood pressure control while minimizing adverse effects.

Disclaimer: This guide is intended for educational purposes and should be adapted to local protocols and individual patient needs. Always refer to current clinical guidelines when making treatment decisions.